Cinnamic acids and derivatives

Selleck Chemical LLC Tyrphostin AG 1296

Tyrphostin AG 1296 is an inhibitor of PDGFR with IC50 of 0 3-0 5 M no activity to EGFR Tyrphostin AG1296 inhibits FGFR and c-Kit with IC50 of 12 3 M and 1 8 M in Swiss 3T3 cells Tyrphostin AG1296 induces dramatic apoptosis in A375R cells

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Medchemexpress LLC Tyrphostin A1 | 2826-26-8 | 98.96% | 184.19 | 50 MG

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Tyrphostin A1 (AG9) inhibits CD40L-stimulated IL-12 production in macrophage cultures and antigen-induced generation of Th1 cells. It blocks CD40L-induced translocation of NF-κB to the nucleus and reduces the activation of the IL-12 p40 gene. In vivo therapy with A1 leads to a decrease in the generation of myelin basic protein (MBP) specific encephalitogenic T cells and attenuates experimental allergic encephalomyelitis (EAE) in SJL/J mice.

• Target: IL-12 production inhibitor
• Dose-dependent decrease of IL-12 p40, with maximal inhibition (62.5%) occurring at a dose of 10 μM
• Significantly weaker inhibitor of TK than other tyrphostins (IC50>1250 μM for epidermal growth factor receptor (EGFR) kinase)
• Useful for differentiating TK-mediated effects of tyrphostins from other non-specific effects

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Medchemexpress LLC Tyrphostin A1 | 2826-26-8 | 99.0% | 184.19 | 100 MG

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Tyrphostin A1 inhibits CD40L-stimulated IL-12 production in macrophage cultures and antigen-induced generation of Th1 cells. It causes a dose-dependent decrease of IL-12 p40 and blocks CD40L-induced translocation of NF-κB to the nucleus, reducing activation of the IL-12 p40 gene. This compound is a weaker inhibitor of TK, often used to differentiate TK-mediated effects from other non-specific effects.

• Inhibits CD40L-stimulated IL-12 production
• Reduces antigen-induced generation of Th1 cells
• Blocks CD40L-induced translocation of NF-κB to the nucleus
• Attenuates experimental allergic encephalomyelitis (EAE) in SJL/J mice
• Useful for differentiating TK-mediated effects from non-specific effects
• For research use only

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Medchemexpress LLC 2-[(3,4-dihydroxy-5-nitrophenyl)methylidene]propanedinitrile | 116313-73-6 | 98.7% | 231.16 g/mol | C10H5N3O4 | 25 MG

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Tyrphostin AG 1288 is a small-molecule tyrosine kinase inhibitor used in biochemical and cellular research to probe tyrosine kinase-dependent signaling pathways, ICAM1 expression, and TNFα-mediated cytotoxicity. It is supplied as a high-purity research reagent intended for in vitro assays.

• High purity suitable for analytical and cell-based assays.
• Useful for investigating tyrosine kinase signaling pathways.
• Inhibits ICAM1 expression and TNFα-mediated cytotoxicity in vitro.
• Supplied as a stable, solid reagent for easy handling and storage.
• Batch-tested with a certificate of analysis for lot verification.
• Compatible with common solvents for assay formulation.

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Apexbio Technology LLC Entacapone 130929-57-6 10mg

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Entacapone (CAS 130929-57-6) is a selective second-generation inhibitor of catechol-O-methyltransferase (COMT) It demonstrates potent inhibition of total COMT in mouse liver with reported IC50 and Ki values of 20 1 nM and 10 7 nM respectively In rat models IC50 values for soluble COMT and membrane-bound COMT are 14 3 nM and 73 3 nM Entacapone is primarily utilized in research as an adjunct to levodopa and dopa decarboxylase inhibitor regimens in Parkinson s disease studies given its ability to suppress the formation of 3-O-methyldopa thereby enhancing levodopa bioavailability and prolonging its pharmacological effect

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Sigma Aldrich Fine Chemicals Biosciences Curcumin United States Pha30mg

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.for further information and support please go to the website of the issuing Pharmacopoeia.

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2-Chlorocinnamic acid, predominantly trans, 99%, Thermo Scientific™

CAS: 3752-25-8 Molecular Formula: C9H7ClO2 Molecular Weight (g/mol): 182.603 MDL Number: MFCD00004372 InChI Key: KJRRTHHNKJBVBO-AATRIKPKSA-N Synonym: 2-chlorocinnamic acid,o-chlorocinnamic acid,3-2-chlorophenyl acrylic acid,2e-3-2-chlorophenyl acrylic acid,e-3-2-chlorophenyl acrylic acid,cinnamic acid, o-chloro,2e-3-2-chlorophenyl prop-2-enoic acid,2-propenoic acid, 3-2-chlorophenyl,e-o-chlorocinnamic acid,3-2-chlorophenyl-2-propenoic acid PubChem CID: 700642 IUPAC Name: (E)-3-(2-chlorophenyl)prop-2-enoic acid SMILES: C1=CC=C(C(=C1)C=CC(=O)O)Cl

α-Cyano-βphenylacrylic Acid, MP Biomedicals

CAS: 1011-92-3 Molecular Formula: C10H7NO2 Molecular Weight (g/mol): 173.171 InChI Key: CDUQMGQIHYISOP-UHFFFAOYSA-N Synonym: 2-cyano-3-phenylacrylic acid,alpha-cyanocinnamicacid,cyanocinnamic acid,2-cyano-3-phenyl-2-propenoic acid,acmc-1b4v0,a-cyano-b-phenylacrylic acid,alpha-cyano-beta-phenyl-acrylic acid PubChem CID: 70534 IUPAC Name: 2-cyano-3-phenylprop-2-enoic acid SMILES: C1=CC=C(C=C1)C=C(C#N)C(=O)O

Cinnamamide, predominantly trans, 97%

CAS: 621-79-4 Molecular Formula: C9H9NO Molecular Weight (g/mol): 147.177 MDL Number: MFCD00008033 InChI Key: APEJMQOBVMLION-VOTSOKGWSA-N Synonym: cinnamamide,trans-cinnamamide,3-phenylacrylamide,cinnamic amide,2-propenamide, 3-phenyl,3-phenylpropenamide,2-benzylideneacetamide,e-cinnamamide,ginnamic acid amide,trans-cinnamoylamine PubChem CID: 5273472 ChEBI: CHEBI:76320 IUPAC Name: (E)-3-phenylprop-2-enamide SMILES: C1=CC=C(C=C1)C=CC(=O)N

α-Fluorocinnamic Acid 98%, Thermo Scientific™

CAS: 350-90-3 Molecular Formula: C9H7FO2 Molecular Weight (g/mol): 166.151 InChI Key: QONCEXMULRJPPY-VURMDHGXSA-N Synonym: alpha-fluorocinnamic acid,.alpha.-fluorocinnamic acid,cinnamic acid, alpha-fluoro,z-alpha-fluorocinnamic acid,2-propenoic acid, 2-fluoro-3-phenyl,z-2-fluoro-3-phenylacrylic acid,2-fluoro-3-phenyl-2-propenoic acid,2z-2-fluoro-3-phenylprop-2-enoic acid,2-fluoro-3-phenylacrylic acid,cinnamic acid, .alpha.-fluoro PubChem CID: 1550911 IUPAC Name: (Z)-2-fluoro-3-phenylprop-2-enoic acid SMILES: C1=CC=C(C=C1)C=C(C(=O)O)F

Thermo Scientific Chemicals Cinanserin hydrochloride, 99+%, Thermo Scientific™

3,4-Dimethoxycinnamic acid, predominantly trans, 99%, Thermo Scientific™

CAS: 2316-26-9 Molecular Formula: C11H12O4 Molecular Weight (g/mol): 208.213 MDL Number: MFCD00004387 InChI Key: HJBWJAPEBGSQPR-GQCTYLIASA-N Synonym: 3,4-dimethoxycinnamic acid,dimethylcaffeic acid,caffeic acid dimethyl ether,2e-3-3,4-dimethoxyphenyl prop-2-enoic acid,dimethyl caffeic acid,e-3-3,4-dimethoxyphenyl acrylic acid,e-3,4-dimethoxycinnamic acid,unii-bvz841pvjl,2e-3-3,4-dimethoxyphenyl acrylic acid,3-3,4-dimethoxyphenyl acrylic acid PubChem CID: 717531 ChEBI: CHEBI:86549 IUPAC Name: (E)-3-(3,4-dimethoxyphenyl)prop-2-enoic acid SMILES: COC1=C(C=C(C=C1)C=CC(=O)O)OC

MP Biomedicals, Inc Sodium Cinnamate, MP Biomedicals

CAS: 538-42-1 Molecular Formula: C9H7NaO2 Molecular Weight (g/mol): 170.14 MDL Number: MFCD00064994 InChI Key: DXIHILNWDOYYCH-UHDJGPCESA-M Synonym: sodium cinnamate,fortificar,cinnamic acid, sodium salt,unii-1dkd3z3e4y,sodium 3-phenyl-2-propenoate,2-propenoic acid, 3-phenyl-, sodium salt,1dkd3z3e4y,cinnamylic acid sodium salt,sodium e-3-phenylprop-2-enoate,potassium cinnamate PubChem CID: 5462638 IUPAC Name: sodium (2E)-3-phenylprop-2-enoate SMILES: [Na+].[O-]C(=O)\C=C\C1=CC=CC=C1

m-Methoxycinnamic Acid, Predominantly trans 97%, Thermo Scientific™

CAS: 6099-04-3 Molecular Formula: C10H10O3 Molecular Weight (g/mol): 178.19 InChI Key: LZPNXAULYJPXEH-AATRIKPKSA-N Synonym: 3-methoxycinnamic acid,3-3-methoxyphenyl acrylic acid,m-methoxycinnamic acid,2e-3-3-methoxyphenyl acrylic acid,2e-3-3-methoxyphenyl prop-2-enoic acid,trans-3-methoxycinnamic acid,e-3-3-methoxyphenyl acrylic acid,trans-3-3-methoxyphenyl acrylic acid,2-propenoic acid, 3-3-methoxyphenyl-, 2e,3-3-methoxyphenyl prop-2-enoic acid PubChem CID: 637668

4-Ethoxycinnamic Acid 98.0+%, TCI America™

CAS: 2373-79-7 Molecular Formula: C11H12O3 Molecular Weight (g/mol): 192.214 MDL Number: MFCD11040581 InChI Key: DZLOUWYGNATKKZ-VMPITWQZSA-N Synonym: 4-ethoxycinnamic acid,3-4-ethoxyphenyl acrylic acid,2e-3-4-ethoxyphenyl acrylic acid,2e-3-4-ethoxyphenyl prop-2-enoic acid,e-3-4-ethoxyphenyl acrylic acid,e-3-4-ethoxyphenyl prop-2-enoic acid,4-ethoxyphenylacrylic acid,p-ethoxycinnamic acid,ethoxyphenylacrylicacid,pubchem8239 PubChem CID: 704218 IUPAC Name: (E)-3-(4-ethoxyphenyl)prop-2-enoic acid SMILES: CCOC1=CC=C(C=C1)C=CC(=O)O