Cinnamic acids and derivatives
TARGETMOL CHEMICALS INC GSK2850163 S ENANTIOMER 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. GSK2850163 (S enantiomer) is the inactive enantiomer of GSK2850163. GSK2850163 is an novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1a). purity: 98%
Apexbio Technology LLC Tyrphostin 9 10537-47-0 25mg
Tyrphostin 9 is a selective inhibitor targeting platelet-derived growth factor receptor (PDGFR) and epidermal growth factor receptor (EGFR) It inhibits PDGFR autophosphorylation with an IC50 of approximately 2 5 M and EGFR kinase activity (IC50 around 460 M) Additionally Tyrphostin 9 inhibits platelet-derived growth factor (PDGF)-stimulated smooth muscle cell proliferation (IC50 approximately 40 nM) as well as phosphorylation of phospholipase C gamma (PLC IC50 2 5 M) and induction of PDGF-dependent c-fos expression In research models Tyrphostin 9 has been utilized to study receptor-mediated signal transduction and vascular injury-related neointimal proliferation processes
Medchemexpress LLC Tyrphostin A9 | 10537-47-0 | MFCD00209853 | 99.9% | 282.38 g/mol | C18H22N2O | 10 MG
Tyrphostin A9 is a small-molecule PDGFR inhibitor provided as an analytical standard for research applications. It is used in biochemical and cell-based studies to investigate tyrosine kinase signaling and mitochondrial dynamics. The material is supplied with purity and storage information and is available in multiple solid and solution formats for laboratory use.
- High purity suitable for analytical and research use.
- Useful as a PDGFR and tyrosine kinase inhibitor in cell and biochemical assays.
- Available in solid and solution formats for flexible experimental workflows.
- Documented stability when stored under recommended conditions.
- Supplied with supporting documentation such as a certificate of analysis or data sheet.
Apexbio Technology LLC Curcumin(Synonyms: Diferuloylmethane, Turmeric yellow, Natural yellow 3, CI 75300), 10mM (in 1mL DMSO), CAS: 458-37-7.
Curcumin (CAS 458-37-7) is a natural small molecule known to inhibit tyrosinase activity with an IC50 of 47 M It modulates multiple signaling pathways involved in tumorigenesis and inflammation influencing transcription factors growth factors cytokines receptors and enzymes Clinical trials at Phase I reported no observed toxicity at doses up to 12 g/day however oral bioavailability is limited ( 1% in Phase I/II studies) Additionally curcumin demonstrates potential for Alzheimer s research as evidenced by reducing beta-amyloid (A 40 A 42) production via downregulating presenilin-1 and GSK-3 in SH-SY5Y neuroblastoma cells
Apexbio Technology LLC Tyrphostin 9 10537-47-0 10mM (in 1mL DMSO)
Tyrphostin 9 is a selective inhibitor targeting platelet-derived growth factor receptor (PDGFR) and epidermal growth factor receptor (EGFR) It inhibits PDGFR autophosphorylation with an IC50 of approximately 2 5 M and EGFR kinase activity (IC50 around 460 M) Additionally Tyrphostin 9 inhibits platelet-derived growth factor (PDGF)-stimulated smooth muscle cell proliferation (IC50 approximately 40 nM) as well as phosphorylation of phospholipase C gamma (PLC IC50 2 5 M) and induction of PDGF-dependent c-fos expression In research models Tyrphostin 9 has been utilized to study receptor-mediated signal transduction and vascular injury-related neointimal proliferation processes
Medchemexpress LLC Tyrphostin 8 | 3785-90-8 | 98.0% | 170.17 g/mol | C10H6N2O | 5 MG
Tyrphostin 8 is a small-molecule tyrosine kinase inhibitor supplied for research use. It inhibits EGFR kinase (IC50 = 560 μM), acts as a GTPase inhibitor, and inhibits calcineurin (IC50 = 21 μM). The compound is provided as a high-purity solid and is available in small-mass vials or as a DMSO solution for in vitro biochemical and cell-based assays.
- High purity (>98%), suitable for in vitro studies.
- Known activity against EGFR, GTPase, and calcineurin targets.
- Molecular weight 170.17 g/mol and formula C10H6N2O.
- Available in multiple small pack sizes and as a 10 mM DMSO solution.
- Light yellow to yellow solid for handling and storage.
Medchemexpress LLC Tyrphostin 8 | 3785-90-8 | MFCD00020189 | 98.0% | 170.17 g/mol | C10H6N2O | 10 MG
Tyrphostin 8 is a small-molecule tyrosine kinase inhibitor used as a research reagent to investigate EGFR signaling and related pathways. The compound is supplied as a light yellow to yellow solid with high reported purity and is offered in multiple solid sizes and DMSO solution formats.
- Inhibits EGFR kinase; reported IC50 ≈ 560 μM
- Also exhibits GTPase inhibitory activity
- High purity for reproducible experimental results
- Available as solid and as 10 mM DMSO solution in multiple sizes
- Storage recommended: solid at 4°C under nitrogen; solutions at -80°C or -20°C
Apexbio Technology LLC Tyrphostin AG 1296 146535-11-7 100mg
Tyrphostin AG 1296 (CAS 146535-11-7) is a selective inhibitor of platelet-derived growth factor receptor (PDGFR) kinase via ATP-competitive binding Its inhibitory activity (IC50 0 3 0 5 M) results from inducing conformational changes in the ATP-binding domain of PDGFR blocking receptor autophosphorylation induced by ligand binding In vitro studies demonstrate inhibition of PDGF-stimulated mitogenesis (IC50 1 5 M) and cell proliferation (IC50 3 2 M) using Swiss 3T3 cells without significant effects on EGF receptor signaling at concentrations up to 100 M Tyrphostin AG 1296 serves as a research tool for investigating PDGFR-mediated signaling pathways
Medchemexpress LLC Ethyl (E)-p-hydroxycinnamate | 7362-39-2 | MFCD00210460 | 99.2% | 192.21 g/mol | C11H12O3 | 10 MG
p-Coumaric Acid Ethyl Ester is the ethyl ester of p-coumaric acid, used in biochemical research as a reversible, non-competitive inhibitor of tyrosinase and as a building block in studies of enzyme inhibition, formulation, and cosmetic or food preservation research.
- Reversible, non-competitive tyrosinase inhibitor (activity reported by manufacturer).
- High purity: 99.19% (manufacturer reported).
- Molecular weight 192.21 g/mol and formula C11H12O3.
- Available as solid (5 mg, 10 mg, 25 mg, 50 mg, 100 mg) and as a 10 mM solution in DMSO for ready-to-use assays.
- Suitable for medicinal, cosmetic, and fruit preservation research applications.
TARGETMOL CHEMICALS INC I-OME-TYRPHOSTIN AG 538 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. I-OMe-Tyrphostin AG 538 is a specific IGF-1R inhibitor and ATP-competitive inhibitor of PI5P4K(alpha) (IC50 1 µM).I-OMe-Tyrphostin AG 538 inhibits IGF-1R-mediated signaling and exhibits preferential cytotoxicity to nutrient-deficient PANC1 cells. purity: 96%
![eMolecules N-(1-[4-(dimethylamino)phenyl]-3-{2-[(4-hydroxy-3-iodo-5-methoxyphenyl)methylidene]hydrazinyl}-3-oxoprop-1-en-2-yl)benzamide | ChemDiv SC |584.414 | C26H25IN4O4COc1cc(\C=N\NC(=O)C(\NC(=O)c2ccccc2)=C/c2ccc(cc2)N(C)C)cc(I)c1O | 2mg | 828451810](https://assets.fishersci.com/TFS-Assets/CCG/product-images/NC3733135.jpg-250.jpg)
eMolecules N-(1-[4-(dimethylamino)phenyl]-3-{2-[(4-hydroxy-3-iodo-5-methoxyphenyl)methylidene]hydrazinyl}-3-oxoprop-1-en-2-yl)benzamide | ChemDiv SC |584.414 | C26H25IN4O4COc1cc(\C=N\NC(=O)C(\NC(=O)c2ccccc2)=C/c2ccc(cc2)N(C)C)cc(I)c1O | 2mg | 828451810
N-(1-[4-(dimethylamino)phenyl]-3-{2-[(4-hydroxy-3-iodo-5-methoxyphenyl)methylidene]hydrazinyl}-3-oxoprop-1-en-2-yl)benzamide | ChemDiv SC |584.414 | C26H25IN4O4COc1cc(\C=N\NC(=O)C(\NC(=O)c2ccccc2)=C/c2ccc(cc2)N(C)C)cc(I)c1O | 2mg | 828451810